Clinical Review of Mosquito-Borne Diseases: Epidemiology, Diagnosis, and Treatment for Healthcare Providers

Published August 19, 2025

Mosquito-borne illnesses remain a public health concern with reported cases doubling over the last two decades.  Increasing global travel of families and the expanding range of mosquito vectors means these diseases are no longer confined to traditionally endemic areas.  Children are uniquely vulnerable to these infections due to differences in immune response, exposure patterns, and diagnostic challenges.

This webpage provides clinicians with a concise yet comprehensive overview of key mosquito-borne diseases affecting children, including their vectors, epidemiology, clinical presentation, diagnostic approaches, and current treatment recommendations. By enhancing awareness and understanding, this guide aims to support timely identification, management, and prevention of these potentially serious illnesses in pediatric care settings. 

The table below provides an overview of each of the illnesses, while subpages linked in the disease collumn provide more detailed information.

Summary Table

Disease Vector(s)Incubation Key Symptoms Diagnostic Test(s)Treatment
West Nile Culex spp.2–6 daysFever, rash, neuroinvasive signsCSF/serum IgM, PCRSupportive
Malaria Anopheles spp.7–30 daysCyclical fevers, chills, anemiaBlood smear, RDTsAntimalarials
Dengue Aedes spp.4–7 daysFever, rash, bleeding riskNS1, IgM/IgG, RT-PCRSupportive
Chikungunya Aedes spp.2–4 daysJoint pain, rash, high feverSerology, RT-PCRSupportive, NSAIDs
Oropouche Culicoides, possible Culex4–8 daysFever, headache, nauseaRT-PCR, ELISASupportive